Functional Heterogeneity of Perivascular Precursor Cells

Autor:	Bruno Péault, Stefano Negri, Jiajia Xu, Aaron W. James, Ching Yun Hsu, Yiyun Wang, Bradley Presson
Rok vydání:	2020
Předmět:	medicine.anatomical_structure Cellular heterogeneity Precursor cell Mesenchymal stem cell Tunica Adventitia medicine Adipose tissue General Medicine Biology Stem cell Perivascular space Stem cell niche Cell biology
Zdroj:	Current Tissue Microenvironment Reports. 1:183-186
ISSN:	2662-4079
Popis:	Tissue-resident mesenchymal precursor cells occupy perivascular spaces. Two main perivascular locations have been described for forerunners of cultured mesenchymal stem cells, including a subendothelial location (termed pericytes) and cells within the tunica adventitia (termed adventitial cells). Emerging data have made clear the cellular heterogeneity within the perivascular stem cell niche. This brief review focuses on two issues. First, the inter-tissue heterogeneity of pericytes, including the theoretical consideration of pericytes as tissue-specific stem cells. Second, the emerging intra-tissue heterogeneity of adventitial cells (a.k.a adventicytes). New data suggest that these fibroblast-like cells within the fat tissue are functionally diverse. Markers that segregate for functionally relevant subsets of adventitial cells will be reviewed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::32e667b1b84d9d38bbef9e4dc105bc34 https://doi.org/10.1007/s43152-020-00019-4 Zobrazit plný text záznamu Full text from SpringerLink