The effect of repetitive transcranial magnetic stimulation add on serotonin reuptake inhibitors in panic disorder
| Autor: | Jan Prasko, Martin Bareš, Beata Pasková, Jiri Horacek, Miloslav Kopecek, Jana Vyskocilova, Tomas Novak, R. Zalesky |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
business.industry
Serotonin reuptake inhibitor Panic disorder medicine.medical_treatment Panic Serotonin reuptake medicine.disease behavioral disciplines and activities Transcranial magnetic stimulation Psychiatry and Mental health Anesthesia mental disorders medicine medicine.symptom Deep transcranial magnetic stimulation Prefrontal cortex business Psychopathology |
| Zdroj: | European Psychiatry. 23:S190-S191 |
| ISSN: | 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2008.01.1039 |
| Popis: | Background:The Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate the cortical activity. The goal of our study was to assess whether the rTMS would facilitate effect of serotonin reuptake inhibitors in patients suffering from panic disorder.Method:Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We used 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study. The psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.Results:Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.Conclusion:The low frequency Repetitive Transcranial Magnetic Stimulation administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham the Repetitive Transcranial Magnetic Stimulation that was add on serotonin reuptake inhibitors in patients suffering from panic disorder.Supported by the project n. MSMT CR 1M0517 |
| Databáze: | OpenAIRE |
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