ChemInform Abstract: A Metal-Free, Three-Component Manifold for the C2-Functionalization of 1-Substituted Imidazoles Operating 'On Water'

Autor:	Fernando García-Tellado, Fabio Cruz‐Acosta, Pedro de Armas
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Chemistry Component (thermodynamics) General Medicine Vinyl ether Combinatorial chemistry law.invention chemistry.chemical_compound Nucleophile Ylide law medicine Imidazole Surface modification Manifold (fluid mechanics) medicine.drug
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201106146
Popis:	A metal-free, three-component process for the C2-func- tionalization of N-alkylated imidazoles is reported The multicom- ponent manifold operates under 'on water' conditions through the formation of a water-stable (permanent) nucleophilic imidazole car- bene (imidazolium ylide). Whereas the incorporated vinyl ether functionality is a convenient handle for further chemical manipula- tion of the functionalized heterocycle (complexity generation), the use of water as the reaction media gives it a bonus of added benefits in terms of safety, bench-friendly processing and environmental care.
Databáze:	OpenAIRE
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