Increased frequency of the apolipoprotein E2 allele in maintenance haemodialysis patients in Taiwan
| Autor: | Shih-Chieh Hsin, Ming-Chia Hsieh, Chao-Sheng Lo, Shiu-Ru Lin, Hung-Chun Chen, Shyi-Jang Shin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Apolipoprotein E
Genetics medicine.medical_specialty Kidney business.industry General Medicine medicine.disease End stage renal disease Diabetic nephropathy Endocrinology medicine.anatomical_structure Nephrology Internal medicine Medicine lipids (amino acids peptides and proteins) Gene polymorphism Allele business Apolipoprotein E2 Allele frequency |
| Zdroj: | Nephrology. 7:277-280 |
| ISSN: | 1440-1797 1320-5358 |
| DOI: | 10.1046/j.1440-1797.2002.00132.x |
| Popis: | SUMMARY: Apolipoprotein E (apo E) regulates the metabolism of lipoproteins. Three different apo E alleles (~2, ~3 and ~4) produce the apo E isoproteins, apo E2, apo E3 and apo E4. Previous studies had revealed that lipid abnormalities might contribute to the development and progression of kidney diseases. Thus, the apo E gene polymorphism may be associated with end-stage renal disease. To investigate the distribution of apo E genotype in patients under haemodialysis in Taiwan, we examined 205 dialysis patients and 103 age-matched normal controls. The apo E gene polymorphism was analysed by the use of polymerase chain reaction. Our study revealed that the frequency of apo E2 allele was significantly higher in dialysis patients (8.0%) than in normal controls (1.9%; P< 0.01). The E3 and E4 allele frequencies were not significantly different between the groups. Our findings indicate that apo E polymorphism was apparently associated with the development of end-stage renal disease in Taiwan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|