The true face of JNK activation in apoptosis

Autor:	Benjamin C. Dibling, Anning Lin
Rok vydání:	2002
Předmět:	Aging chemistry.chemical_compound Crosstalk (biology) chemistry Apoptosis JNK Pathway NF-κB Cell Biology Biology JNK Mitogen-Activated Protein Kinases Cell biology
Zdroj:	Aging Cell. 1:112-116
ISSN:	1474-9726 1474-9718
DOI:	10.1046/j.1474-9728.2002.00014.x
Popis:	Age-associated changes in apoptotic rates have been observed in a number of different tissues. While the implications of these findings remain unclear, a better understanding of how apoptosis is regulated may further our understanding of the aging process. The role of the JNK pathway in apoptosis has been highly controversial with studies suggesting that it plays a pro-apoptotic, anti-apoptotic or no role in this process. Here we discuss what is currently known about JNK's role in apoptosis, highlighting recent findings regarding NF-kappaB-mediated inhibition of JNK activation and its impact on TNF-alpha induced apoptosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::32cce351fdaac73f67bdb691065df0b9 https://doi.org/10.1046/j.1474-9728.2002.00014.x Zobrazit plný text záznamu Plný text