68Ga-Labeled bismacrocyclic methylene phosphonate as potential bone seeking PET radiopharmaceutical
| Autor: | Garima Mann, Himanshu Ojha, Ambika Jaswal, Anil Mishra, Anupama Datta, Kanchan Chauhan |
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| Rok vydání: | 2020 |
| Předmět: |
PET-CT
medicine.diagnostic_test 010405 organic chemistry Organic Chemistry Radiochemistry Pet imaging Bone imaging 01 natural sciences Biochemistry Phosphonate 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Positron emission tomography Drug Discovery medicine DOTA Methylene Molecular Biology |
| Zdroj: | Bioorganic Chemistry. 104:104185 |
| ISSN: | 0045-2068 |
| Popis: | Phosphonates-based agents are well-known bone-seeking radiopharmaceuticals with application in detection and therapy. With higher sensitivity and resolution offered by Positron Emission Tomography (PET), tracers based on this technique are gaining huge attention. 68Ga-based generator and radiotracers render independence from the on-site cyclotron. We report the development of 68Ga-labeled DOTA-based bismacrocyclic phosphonate derivative, for bone PET imaging. The synthesis and characterization of 68Ga- DO3P-AME-DO3P was carried out in > 95% purity. The radiotracer displayed high stability and low binding affinity ( |
| Databáze: | OpenAIRE |
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