Use of fat suppression in R2 relaxometry with MRI for the quantification of tissue iron overload in beta-thalassemic patients
| Autor: | Maria Mademli, Nikos Economopoulos, Nikolaos Kelekis, Efthymia Alexopoulou, Odysseas Benekos, Alexia Balanika, Kostantina Foufa, Olympia Papakonstantinou |
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| Rok vydání: | 2012 |
| Předmět: |
Relaxometry
business.industry Chemistry Tissue iron Biomedical Engineering Biophysics Fat suppression Spleen Nuclear magnetic resonance medicine.anatomical_structure Relaxation rate medicine Radiology Nuclear Medicine and imaging Nuclear medicine business Pancreas Beta (finance) Vertebral bone marrow |
| Zdroj: | Magnetic Resonance Imaging. 30:926-933 |
| ISSN: | 0730-725X |
| Popis: | Purpose To assess the performance and results of R2 relaxometry using a fat-suppressed (FS) multiecho sequence and compare these to conventional R2 relaxometry in estimating tissue iron overload. Materials and Methods Relaxation rate values (R2=1/T2) of the liver, spleen, pancreas and vertebral bone marrow (VBM) were estimated in 21 patients with β-thalassemia major, using a respiratory-triggered 16-echo Carr-Purcell-Meiboom-Gill (CPMG) spin-echo sequence before (R2) and after (R2 FS) the application of chemically selective fat suppression. Results Hepatic and splenic R2 FS values correlated with respective R2 values (r=0.98 and r=0.96, P Conclusion Application of fat suppression in the standard CPMG sequence improved the capability of MRI in noninvasive quantification of iron, particularly in lipid-rich tissues, such as vertebral bone marrow (VBM) and pancreas. |
| Databáze: | OpenAIRE |
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