Review Article: Chronobiology and Asthma. III. Timing Corticotherapy to Biological Rhythms to Optimize Treatment Goals
| Autor: | A. Reinberg, J. P. McGovern, Gilbert E. D'Alonzo, Michael H. Smolensky |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chronobiology medicine.medical_specialty Evening business.industry Adrenal cortex Period (gene) medicine.disease Rhythm medicine.anatomical_structure Endocrinology Internal medicine Pediatrics Perinatology and Child Health medicine Immunology and Allergy Circadian rhythm business Asthma Hormone |
| Zdroj: | Journal of Asthma. 25:219-248 |
| ISSN: | 1532-4303 0277-0903 |
| DOI: | 10.3109/02770908809071368 |
| Popis: | Synthetic corticosteroids are frequently used to manage asthma and other inflammatory diseases. The timing of such drugs (whether ingested, inhaled, or infused) in relation to body rhythms influences the magnitude of both desired and undesired effects. It is crucial that corticotherapy be correctly scheduled to the circadian system of the hypothalamic-pituitary-adrenocortical (HPA) system. The secretion of cortisol from the adrenal cortex is not constant during each 24-hour period. Instead, production of this hormone varies as a high-amplitude circadian rhythm, with most of the secretion taking place during the initial hours of the activity span and very little late in the evening and during the first half of the sleep span. Results of laboratory and human studies indicate that the timing of exogenous corticosteroids, in relation to the circadian rhythm in HPA activity, is a critical factor. For example, the optimization of corticosteroid therapy for asthmatics entails daily (or alternate-day) administrat... |
| Databáze: | OpenAIRE |
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