| Popis: |
We developed a miniswine model of passive heatstroke, in part, to explain the variable hyper-, normo- and hypokalemia seen in heatstroke victims. After a baseline period ( T amb =26–27°C), anesthetized and instrumented miniswine ( n =13, mass=44.6 kg) were ramped to 41–43°C, 60% RH; 13 controls were treated identically, but T re was maintained at 38°C. T re of the experimental miniswine rose nearly linearly to 45–46°C until death (approx. 4 h). The response patterns of mean arterial pressure, heart rate, plasma K + , LPS, Ca 2+ , inorganic phosphate, lactate and a variety of other clinical chemical and physiological variables were determined. An explanation for the variability of plasma K + in heatstroke victims was proposed. This model may be useful in characterizing the multisystemic pathology of severe heat injury and be useful for assessing innovative therapeutic regimens. |
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