Sex- and Strain-dependent Effects of Bisphenol: A Consumption in Juvenile Mice
| Autor: | Jessica R Gooding, Shawn R. Campagna, Suchita Das, Arnold M. Saxton, Stephen P. Dearth, Brantley S Wyatt, Brynn H. Voy |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty urogenital system business.industry Metabolite Adipose tissue Adipokine Type 2 diabetes medicine.disease Obesity 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Endocrinology Insulin resistance chemistry Adipogenesis Diabetes mellitus Internal medicine medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Diabetes & Metabolism. 7 |
| ISSN: | 2155-6156 |
| Popis: | Children are directly exposed to bisphenol A (BPA) and other putative environmental obesogens through both diet and household products. The purpose of this study was to investigate sex- and genetic-dependent effects of BPA consumption on traits relevant to obesity and Type 2 diabetes in juveniles, using mice as models. Two strains of mice (C57BL/6J and DBA/2J) were chosen to represent distinct genetic backgrounds that differ in susceptibility to obesity and insulin resistance. Male and female mice of each strain consumed BPA at three doses in drinking water from four to eleven weeks of age. Male but not female mice of each strain consuming BPA were significantly fatter than controls. BPA induced corresponding changes in adipose tissue gene expression and metabolite abundance that indicate effects on adipogenesis and energy utilization. BPA consumption also altered the synthesis of adipokines, circulating factors that modulate insulin sensitivity and atherogenesis, in C57BL/6J but not DBA/2J males. Conversely, effects of BPA on plasma insulin were only observed in female mice, and with opposite effects in the two strains. These results suggest that dietary BPA may exacerbate childhood obesity and its consequences, and that sex and genetic background are important determinants of the physiological impact of BPA. |
| Databáze: | OpenAIRE |
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