Native Fibrin Gel Networks and Factors Influencing their Formation in Health and Disease

Autor: Birgit Hessel, Angela Silveira, Roman Procyk, Kjell Carlsson, Birger Blombäck, L. Zacharski, D. Banerjee, Anders Hamsten
Rok vydání: 1990
Předmět:
Zdroj: Advances in Experimental Medicine and Biology ISBN: 9781461366973
DOI: 10.1007/978-1-4615-3806-6_1
Popis: Hydrated fibrin gels were studied by confocal laser 3D microscopy, liquid permeation and turbidity. The gels from normal fibrinogen were found to be composed of straight rod-like fiber elements which sometimes originated from denser nodes. In gels formed at increasing thrombin or fibrinogen concentrations, the gel networks became tighter and the porosity decreased. The fiber strands also became shorter. Gel porosity of the network decreased dramatically in gels formed at increasing ionic strengths. Shortening of the fibers were observed and fiber swelling occurred at ionic strength above 0.24.
Databáze: OpenAIRE