Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a CDH1 Gene Germline Mutation

Autor:	Ana Luísa Cunha, Cláudia Pinto, Mário Dinis-Ribeiro, Catarina Brandão, Ângelo Rodrigues, Renata Dias
Rok vydání:	2021
Předmět:	biology business.industry Gastroenterology MALT lymphoma medicine.disease digestive system diseases CDH1 Surveillance endoscopy Germline mutation Cancer research biology.protein Medicine business Gene
Zdroj:	GE - Portuguese Journal of Gastroenterology. 29:51-55
ISSN:	2387-1954 2341-4545
DOI:	10.1159/000514652
Popis:	Carriers of the mutated CDH1 gene have an increased risk of developing early-onset signet-ring cell (diffuse) gastric cancer. We present a case of a young patient with a confirmed mutation of the CDH1 gene, who was diagnosed with a gastric marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) from surveillance endoscopy. He underwent Helicobacter pylori eradication treatment and was subsequently submitted to a total prophylactic gastrectomy. The surgical specimen only revealed foci of signet-ring cell carcinoma (SRCC) in situ without lymphoma signs. We highlight here the occurrence of other pathology in high-risk patients as well as its possible influence on the decision to perform gastrectomy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::328e953ddbf80d578cb93c09e499ab14 https://doi.org/10.1159/000514652 Zobrazit plný text záznamu