Neuroimaging studies of fronto-limbic dysfunction in geriatric depression
| Autor: | Jose M. de Asis, Emily Stern, Hong Pan, Robert C. Young, David Silbersweig |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.diagnostic_test
Treatment outcome Neuropsychology Psychiatry and Mental health Neuropsychology and Physiological Psychology Neurology Neuroimaging Frontal lobe Positron emission tomography Functional neuroimaging medicine Neurology (clinical) Psychology Neurocognitive Neuroscience Biological Psychiatry Depression (differential diagnoses) |
| Zdroj: | Clinical Neuroscience Research. 2:324-330 |
| ISSN: | 1566-2772 |
| DOI: | 10.1016/s1566-2772(03)00009-4 |
| Popis: | Geriatric depression (GD) is an increasingly prevalent condition with specific clinical features and comorbidities. The neurobiology of this condition has only recently begun to be elucidated. The structural and functional neuroimaging literature relevant to a systems-level neurobiological understanding of GD is reviewed. A positron emission tomography (PET) imaging activation study of GD is described. This study utilized neurocognitive activation probes, as well as resting measures, to examine fronto-limbic abnormalities associated with clinical features, neuropsychological profiles, and treatment outcome in GD. Such ongoing work helps to establish models and test hypotheses concerning the neural substrates and pathophysiology of this devastating neuropsychiatric condition. In so doing, it provides a foundation for the development of more specific, biologically-based diagnostic and treatment strategies. |
| Databáze: | OpenAIRE |
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