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Aims: Rhizophora apiculata is a traditional medicine used to treat pain, ulcer, and inflammation in southeast coast of India without scientific evidence. Therefore, we aimed to evaluate antinociceptive effect of R. apiculata to chemical and thermal induced nociceptive models. Place and Duration of Study: Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamil Nadu, India, between June 2012 and September 2012. Methodology: Albino mice received 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction (Alk-CF) by orally and dose-dependently decreased the writhing numbers (P |