Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
| Autor: | Prakash Shetty, Prashanth Shetty, Nishitha Isloor, Arun M. Isloor, S. R. Ubaradka |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Drug Chemistry medicine.drug_class medicine.medical_treatment media_common.quotation_subject Organic Chemistry Pharmacology toxicology Diclofenac Sodium Aldehyde Anti-inflammatory Anticonvulsant medicine Organic chemistry Moiety General Pharmacology Toxicology and Pharmaceutics Diazepam media_common medicine.drug |
| Zdroj: | Medicinal Chemistry Research. 22:1497-1503 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-012-0103-1 |
| Popis: | In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N′-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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