Functional role of fertility α2
| Autor: | Gennady T. Sukhikh, I. M. Bogdanova, D. D. Petrunin, V. V. Malaitsev |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Spermatozoon media_common.quotation_subject Trophoblast Fertility General Medicine Biology Endometrium General Biochemistry Genetics and Molecular Biology Cell biology medicine.anatomical_structure Human fertilization Endocrinology Internal medicine medicine Gestation Function (biology) Menstrual cycle media_common |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 126:965-972 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02447294 |
| Popis: | Fertility α2-microglobulin is one of the main proteins expressed between the late lutein phase of the menstrual cycle and the first gestation trimester. It is produced by endometrial secretory glandular epithelium and decidual membrane. It is believed to be involved in the preparation to gestation, conception, normal development of the fetoplacental system, and initiation of labor. The immunomodulating, effect of fertility α2-microglobulin and its possible involvement in the regulation of fertilization by blocking the spermatozoon reaction with the ovocyte lucid membrane were demonstratedin vitro. The data of structural analysis (appurtenance to lipocalines and unique pattern of N-glycosylation) and analysis of the spatial and temporal parameters of the expression in connection with other events in the organism within the same system of coordinates propated us to investigate the probability of realization of other, so far unknown functions of α2-microglobulin. The probable mechanisms of realization of the immunomodulating function are analyzed. |
| Databáze: | OpenAIRE |
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