ChemInform Abstract: Synthesis of Optically Active 1,2-Indene Oxide and Vicinal cis-Aminoindanols via Asymmetric Reduction of 2-Tolylsulfonyloxy-1-indanone with (-)-B-Chlorodiisopinocampheylborane

Autor:	Ok Kyoung Choi, Byung Tae Cho
Rok vydání:	2010
Předmět:	Stereochemistry Oxide General Medicine Diethylzinc Optically active Protease inhibitor (biology) chemistry.chemical_compound Orally active chemistry Aldol reaction medicine Indene Vicinal medicine.drug
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200228129
Popis:	and Ok Kyoung ChoiDepartment of Chemistry, Hallym University, Chunchon, Kangwondo 200-702, KoreaReceived July 18, 2001Keywords : (−)-B-Chlorodiisopinocampheylborane, (1S,2R)-1,2-Indene oxide, (1S,2R)-1-Amino-2-indanol,(1S,2R)-2-Amino-1-indanol, Asymmetric reduction.Optically active vicinal cis-aminoindanols such as (1S,2R)-1-amino-2-indanol 1 and (1S,2R)-2-amino-1-indanol 2 areimportant substances which can be widely used as a vitalsource of an orally active HIV-1 protease inhibitor, Indinavir,and as chiral ligands or auxiliaries for chiral stationary phaseand asymmetric transformations including carbonyl reductions,aldol reactions, diethylzinc addition to aldehydes and Diels-Alder reactions.
Databáze:	OpenAIRE
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