Effects of Intermittent Nebulization of NONOate, DPTA/NO, on Group B Streptococcus-Induced Pulmonary Hypertension in Newborn Piglets
| Autor: | Eduardo Bancalari, Katarzyna Dabrowska, John Ladino, Cleide Suguihara, Dorothy Hehre |
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| Rok vydání: | 2010 |
| Předmět: |
Streptococcus
business.industry Treatment outcome medicine.disease_cause medicine.disease Pulmonary hypertension NONOate Group B Nitric oxide chemistry.chemical_compound Streptococcus agalactiae chemistry Anesthesia Pediatrics Perinatology and Child Health medicine business STREPTOCOCCAL INFECTIONS Developmental Biology |
| Zdroj: | Neonatology. 99:57-64 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Background: A single dose of NONOate attenuates pulmonary hypertension (PH) induced by group B Streptococcus (GBS) infusion and this is accompanied by a decrease in systemic vascular resistance (SVR). Objective: The objective of the study was to determine whether two doses of the NONOate sustain the attenuation in GBS-induced PH without further systemic compromise. Methods: 15 anesthetized newborn piglets were randomized to receive placebo (n = 8) or two doses of nebulized DPTA/NO (n = 7) at 15 and 75 min after GBS-induced PH. Pulmonary artery (Ppa) and systemic (Psa) pressures, cardiac output (CO) and arterial blood gases were obtained at baseline and every 15 min until 180 min during GBS infusion. Results: Ppa and pulmonary vascular resistance (PVR) decreased significantly after the first dose of nebulized DPTA/NO and this effect was maintained after the second dose. Psa and SVR decreased after the first dose of DPTA/NO to values close to baseline and no further changes in systemic circulation were observed with repeated treatment. PVR/SVR increased with GBS infusion, but decreased after the first dose of DPTA/NO and remained significantly lower for 180 min. CO was significantly higher in the DPTA/NO group. Changes in Ppa, PVR, Psa, SVR, and CO with GBS infusion were not modified by placebo infusion. PaCO2, base deficit, and pH did not differ between groups. PaO2 was significantly lower in the DPTA/NO group after the second dose. Conclusion: These data demonstrated that GBS-induced PH is attenuated with two doses of DPTA/NO without significant systemic effect. The vasodilatory effect is more pronounced in the pulmonary than in the systemic vasculature, as suggested by lower PVR/SVR in the DPTA/NO group. We speculate that NONOates may have a clinical application in the management of PH in neonates. |
| Databáze: | OpenAIRE |
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