Thrombin Activity Associated with Indwelling Central Venous Catheters

Autor:	Charles W. Francis, Julie V. Braaten, Andrew H Felcher, Rachel A. Goss, Janice White
Rok vydání:	1997
Předmět:	medicine.medical_specialty Vascular disease business.industry Hirudin Urology Hematology medicine.disease Thrombosis Surgery Pathogenesis Catheter Thrombin Thrombin activity medicine business Complication medicine.drug
Zdroj:	Thrombosis and Haemostasis. 77:048-052
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1655905
Popis:	SummaryThrombotic complications are frequent with indwelling central venous catheters and result in catheter dysfunction, vascular obstruction and may also contribute to catheter-associated infections. The pathogenesis of catheter thrombosis is not well characterized but may involve vessel damage, local stasis and catheter-associated thrombin formation. We have, therefore, measured the thrombin activity associated with central venous catheters removed from patients and have also determined the ability of hirudin to inactivate catheter-associated thrombin. We obtained 48 catheters from 46 patients and removed 1 cm portions for study. These were taken from the distal end, 5 cm proximal, and 15 cm proximal from the end. Following washing, thrombin activity was measured with a chromogenic assay. Thrombin was associated with 40 of 48 catheters and with 100 of 144 segments with a mean activity of 132 ± 27 μU/cm with a range of 0 to 2,160 μU/cm. Incubation in hirudin reduced the activity from a mean of 122 ± 33 μU/cm to 18 ± 6 μU/cm (p
Databáze:	OpenAIRE
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