Eradication Therapy in Helicobacter pylori-Positive Patients with Halitosis: Long-Term Outcome
| Autor: | Ioannis Triantafillidis, Themistoklis Vasiliadis, Panagiotis Katsinelos, Kostas Tziomalos, Basilis Papaziogas, Grigoris Chatzimavroudis, George Paroutoglou, Taxiarchis Katsinelos, Ioannis Pilpilidis |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
biology business.industry Incidence (epidemiology) Anti-ulcer Agent digestive oral and skin physiology Treatment outcome macromolecular substances General Medicine Amoxicillin Helicobacter pylori biology.organism_classification digestive system diseases Pharmacotherapy Clarithromycin Internal medicine medicine In patient business medicine.drug |
| Zdroj: | Medical Principles and Practice. 16:119-123 |
| ISSN: | 1423-0151 1011-7571 |
| DOI: | 10.1159/000098364 |
| Popis: | Objective: The aim of this study was to investigate the incidence and long-term outcome of halitosis before and after eradication therapy in patients with functional dyspepsia and Helicobacter pylori infection. Subjects and Methods: Halitosis and dyspepsia-related symptoms were investigated by way of a questionnaire. Only patients with functional dyspepsia, H. pylori infection and no histological evidence of atrophy were included in the study. A total of 18 patients fulfilled these criteria and completed the study. Four to six weeks after the end of eradication treatment, endoscopy or [13C] breath test was performed to check for H. pylori in the gastric mucosa. Halitosis and dyspeptic symptoms were re-evaluated during and at the end of follow-up. Results:H. pylori infection was eradicated in all patients, in the 14/18 patients (77.8%) with triple drug therapy, and the 4/18 patients (22.2%) with quadruple drug therapy. During the follow-up period (mean 55.8 ± 21.3 months (range 6–108 months)) resolution of halitosis was observed in 16/18 patients (88.9%), while 2 patients (11.1%) (p < 0.001) continued to present with halitosis. Also, eradication therapy resulted in statistically significant relief of all dyspeptic symptoms, except bloating. Conclusion: Eradication of H. pylori in patients with functional dyspepsia and halitosis results in sustained resolution of halitosis during long-term follow-up in the majority of cases. This finding supports the existence of a link between H. pylori infection and halitosis and suggests that H. pylori eradication might be considered in patients with halitosis. |
| Databáze: | OpenAIRE |
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