Lack of effect of vitamin B-6 supplementation on the lipoprotein profile of post-menopausal chronic hemodialysis patients
| Autor: | George U. Liepa, Ronald C. Prati, M.A. Gorman, Carolyn Cochran, Suzanne Pike, Jessie Ashby |
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| Rok vydání: | 1990 |
| Předmět: |
Vitamin
medicine.medical_specialty Nutrition and Dietetics Diet therapy Cholesterol business.industry medicine.medical_treatment Pyridoxine chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine lipids (amino acids peptides and proteins) Hemodialysis business Pyridoxine Hydrochloride Dialysis Food Science Lipoprotein medicine.drug |
| Zdroj: | Journal of the American Dietetic Association. 90:968-972 |
| ISSN: | 0002-8223 |
| DOI: | 10.1016/s0002-8223(21)01672-2 |
| Popis: | This study was designed to analyze the effect of vitamin B-6 supplementation on the lipoprotein profile of chronic hemodialysis patients. Individuals on chronic hemodialysis experience an acceleration of atherosclerosis, which is often accompanied by abnormal lipid metabolism. Although total plasma cholesterol is usually normal, high-density-lipoprotein (HDL) cholesterol is often low. Recently, it has been suggested that the development of atherosclerotic lesions in chronic hemodialysis patients may be the result of a decreased plasma concentration of pyridoxal 5’-phosphate (PLP) and concomitant alterations in plasma amino acid and/or lipoprotein profiles. All subjects in this study were supplemented with 0.97 mmol (200 mg) pyridoxine hydrochloride per day for 28 days; then, concentrations of PLP, total cholesterol, and lipoprotein cholesterol fractions were determined in the plasma. No significant difference was noted in PLP concentration between Group 1 (five post-menopausal women with a history of atherosclerosis who were undergoing maintenance hemodialysis therapy) and Group 2 (six subjects who were non-symptomatic). However, both groups had significant increases in PLP concentrations between the pre- and post-supplementation periods (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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