Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment
| Autor: | Xiaohong Cui, Shuo-Wen Huang, Li-Wei Qiu, Hong-Jun Xie, Yi-Fei Liu, Haijian Zhang, Xiao-Qing Cao, Xian Ye, Yan Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Mechanism (biology)
Effector Immune microenvironment Gastroenterology Cancer General Medicine Biology medicine.disease medicine.disease_cause digestive system diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Hepatocellular carcinoma medicine Cancer research 030211 gastroenterology & hepatology Primary liver cancer Carcinogenesis neoplasms Annexin A2 |
| Zdroj: | World Journal of Gastroenterology. 26:2126-2137 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v26.i18.2126 |
| Popis: | Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future. |
| Databáze: | OpenAIRE |
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