Polyfunctional imidazoles: XIV. 4-sulfonyl-5-formyl-1H-imidazoles

Autor:	A. N. Grozav, M. V. Vovk, V. I. Dorokhov, V. A. Chornous
Rok vydání:	2017
Předmět:	Sulfonyl chemistry.chemical_classification 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry 010405 organic chemistry Aryl Organic Chemistry Sodium azide Phenols 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Russian Journal of Organic Chemistry. 53:1548-1555
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428017100104
Popis:	Oxidative chlorination of 1-aryl-4-benzylsulfanyl-1H-imidazole-5-carbaldehydes gave 1-aryl-5-formyl-1H-imidazole-4-sulfonyl chlorides which reacted with secondary amines and phenols to produce the corresponding N,N-disubstituted 5-formylimidazole-4-sulfonamides and aryl sulfonates. The reaction of 1-aryl-5-formyl-1H-imidazole-4-sulfonyl chlorides with sodium azide, followed by reduction of the resulting sulfonyl azides, led to the formation of N-unsubstituted 5-formylimidazole-4-sulfonamides, and the reaction with alcohols, to 5-formylimidazole-4-sulfonic acids.
Databáze:	OpenAIRE
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