Sa1232 Validation of a Novel Clinical Prediction Scale for Hospital-Onset Clostridium difficile Infection Confirmed Using Polymerase Chain Reaction Assay

Autor:	Niraj Jani, Subhash Chandra, Erez A. Minka, Margarita Noel, Rameet Thapa, Surendra Marur
Rok vydání:	2013
Předmět:	Hepatology business.industry Gastroenterology Clostridium difficile Antimicrobial Taurocholic acid Pact Microbiology Spore law.invention chemistry.chemical_compound chemistry law Toxicity Medicine business Polymerase chain reaction
Zdroj:	Gastroenterology. 144:S-237
ISSN:	0016-5085
DOI:	10.1016/s0016-5085(13)60838-0
Popis:	the treatment. . Remarkably, it was shown that pre-incubation of CD spores in germination conditions for 30 minutes prior to PACT leads to .99.9 % kill of the initial number of spores permitting the killing of CD in both its vegetative and sporulating form. Moreover, toxicity of taurocholic acid was excluded in HT-29 colon cells. Conclusion: The presented study describes applicability for PACT in the successful treatment of highly resistant CD spores using a two-phase antimicrobial approach and that taurocholic acid is non-toxic to humans. This strategy could be effective at reducing the significant numbers of patients with relapsing CD, the length of stay for these patients, associated morbidity as well as the potential mortality of CD which mostly arises from this sub-group of patients.
Databáze:	OpenAIRE
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