Uptake of the photosensitizer tin ethyl etiopupurin by the canine prostate and its tissue effects when combined with red light
| Autor: | Rick W. Keck, Sandra L. DeHoratius, Hugh L. Narciso, Aaron F. Wittenberg, Daniel R. Doiron, Steven H. Selman |
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| Rok vydání: | 1995 |
| Předmět: |
Canine prostate
Pathology medicine.medical_specialty Materials science Urinary bladder medicine.medical_treatment chemistry.chemical_element Photodynamic therapy equipment and supplies medicine.disease medicine.anatomical_structure chemistry Tin ethyl etiopurpurin Prostate medicine Adenocarcinoma Photosensitizer Tin |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.208171 |
| Popis: | A series of experiments was undertaken to determine the uptake of the photosensitizer tin ethyl etiopurpurin in the canine prostate. At increasing time intervals after intravenous injection, tissue photosensitizer levels were determined for the prostate, urinary bladder and other selected sites. Tissue effects resulting from either transurethral or transperineal delivery of light to the prostate after tin ethyl etiopurpurin-photosensitization were then assessed by light microscopy. Both resulted in hemorrhagic necrosis of the target prostatic tissue. Photodynamic therapy of the prostate using tin ethyl etiopurpurin as photosensitizer for the treatment of both benign prostatic enlargement and adenocarcinoma is worth of further investigation. |
| Databáze: | OpenAIRE |
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