Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans
| Autor: | Liubov Koval, Nadezhda Zemskaya, Alex Zhavoronkov, Eugenia V. Schegoleva, Mikhail V. Shaposhnikov, Alexey Moskalev |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Antioxidant medicine.medical_treatment media_common.quotation_subject SOD1 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Melanogaster Gene media_common chemistry.chemical_classification biology Chemistry Longevity Hormesis Cell Biology Geroprotector biology.organism_classification Amino acid 030104 developmental biology Endocrinology 030217 neurology & neurosurgery |
| Zdroj: | Aging. 10:2428-2458 |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.101561 |
| Popis: | N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects of NAC at 8 different concentrations (from 10 nM to 100 mM) on the lifespan, stress-resistance and locomotor activity. Except the adverse effects of highest (10 mM and 100 mM) concentrations NAC demonstrated sexually opposite and male-biased effects on Drosophila lifespan, stress-resistance and locomotor activity and not satisfied the criteria of a geroprotector in terms of the reproducibility of lifespan extending effects in different model organisms. The concentration- and sex-dependent changes in the relative expression levels of the antioxidant genes (Cat/CG6871 and Sod1/CG11793) and genes involved in hydrogen sulfide biosynthesis (Cbs/CG1753, Eip55E/CG5345 and Nfs1/CG12264) suggest the involvement of hormetic mechanisms in the geroprotective effects of NAC. |
| Databáze: | OpenAIRE |
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