| Autor: |
Naohide Sato, Takemasa Ohki, Hiroyoshi Suzuki, Tetsuro Onishi, Kazuo Mikami, Ken-ichi Egoshi, Akira Komiya, Hiroomi Nakatsu, Sho Ota, Yukio Naya, Tomohiko Ichikawa, Yusuke Awa, Kazuhiro Araki |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
International Journal of Urology. 17:555-562 |
| ISSN: |
0919-8172 |
| Popis: |
Objectives: To investigate the benefit of α1-adrenoceptor antagonist naftopidil on the quality of life (QOL) of patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). Methods: A total of 99 men with BPH/LUTS were prospectively recruited. The Short Form-8 (SF-8) was used for generic QOL assessment and each parameter was compared with the norm in these patients. Longitudinal changes were evaluated using the SF-8 and the International Prostatic Symptoms Score (I-PSS) at baseline, 4 and 8 weeks after naftopidil administration. The relationship between SF-8 and I-PSS was analyzed. Results: Five of eight components in the SF-8 were significantly lower than the Japanese national norm at baseline. SF-8 score was improved by naftopidil at 4 and 8 weeks in general health (GH) and physical component summary (PCS) in the patients in their 70s. Mental health (MH) and mental component summary (MCS) were improved at 8 weeks in patients in their 60s. When analyzing the whole cohort, SF-8 GH, role emotional (RE) and MH had improved at 8 weeks, which was similar to the norm, and bodily pain (BP) results were better. Compared with the baseline, total I-PSS, storage/voiding symptoms and QOL index scores improved significantly under naftopidil. Each component of I-PSS (except for hesitancy) correlated with SF-8 sub-scales (except for BP) to some extent. Conclusions: BPH/LUTS impairs generic QOL, which is improved by naftopidil treatment. SF-8 can be a useful instrument to assess the efficacy of BPH/LUTS treatment because its simplicity to complete and analyze, and its meaningful relationship to I-PSS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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