A Lindqvist-type [W6O19]2‒ organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action
| Autor: | Xiaoyuan Guo, Jiangnan Chang, Lihua Ma, Yan-Zhen Li, Meng Zhao, Ming-Xue Li, Xiyu Zhu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Stereochemistry Respiratory chain Glutathione medicine.disease_cause chemistry.chemical_compound Minimum inhibitory concentration Mechanism of action chemistry Staphylococcus aureus medicine medicine.symptom Antibacterial activity Escherichia coli |
| Zdroj: | Tungsten. 4:121-129 |
| ISSN: | 2661-8036 2661-8028 |
| DOI: | 10.1007/s42864-021-00073-x |
| Popis: | In this paper, a new organic–inorganic hybrid compound [Co(L)2]2[W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg·mL−1) and Escherichia coli (E. coli, 0.24 µg·mL−1), respectively. Furthermore, the potential mechanism of compound 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases (RCD) activity, destruction of reactive oxygen species (ROS) and depletion of glutathione (GSH). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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