A new synthetic route to chiral 3-aryl-5-ethyl-1,4,2-oxazaphosphorines

Autor:	Vladimir A. Alfonsov, K. E. Metlushka, Zilya Yamaleeva, Olga N. Kataeva, Kamil A. Ivshin, D. N. Sadkova, K. A. Nikitina
Rok vydání:	2018
Předmět:	chemistry.chemical_compound Enantiopure drug 010405 organic chemistry Chemistry Aryl Aromatic fragment Trifluoroacetic acid General Chemistry Alkylation 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Mendeleev Communications. 28:579-581
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2018.11.004
Popis:	Diastereoselective synthesis of racemic and enantiopure 3-aryl-5-ethyl-1,4,2-oxazaphosphorines, including those bearing phenolic hydroxyl groups in the exocyclic aromatic fragment, was implemented by the reaction of imines derived from (±)-and (R)-(−)-2-aminobutan-1-ol and (hydroxy)benzaldehydes with triethyl phosphite and trifluoroacetic acid, followed by the one-pot dealkylation of the intermediate esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::323cb95233f6e35b42f9f2f918a36148 https://doi.org/10.1016/j.mencom.2018.11.004 Zobrazit plný text záznamu Full Text from ScienceDirect