The Application, Neurotoxicity, and Related Mechanisms of Silver Nanoparticles
| Autor: | L. Strużyńska |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species biology Amyloid beta Neurodegeneration Neurotoxicity Excitotoxicity 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease_cause medicine.disease Blood–brain barrier Silver nanoparticle Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure chemistry medicine biology.protein 0210 nano-technology Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| DOI: | 10.1016/b978-0-12-804598-5.00007-6 |
| Popis: | Nanotechnology has developed at a rapid pace in recent years. Silver nanoparticles (AgNPs) are widely used in many different applications because they have strong antimicrobial effects and are also gaining in importance as promising “nanotools” for therapeutic and diagnostic purposes, including treatment of central nervous system disorders. For these reasons, research on the potential neurotoxicity of AgNPs is needed, particularly because AgNPs have the ability to enter the brain and significantly accumulate in this organ. Although easily translocated through the blood–brain barrier, AgNPs exert toxic effects toward microvessels and adjacent cells in parenchyma. They deplete antioxidant defense mechanisms leading to the production of reactive oxygen species and oxidative stress with neuronal cell death as a final result. New lines of investigation have identified the involvement of N-methyl- d -aspartate glutamate receptors and amyloid beta in AgNP-induced neurotoxicity. Evaluation of toxic mechanisms is required in this new age of development of nanomedicine. |
| Databáze: | OpenAIRE |
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