Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer
| Autor: | Timo Atula, Antti A. Mäkitie, Jaana Hagström, Laura K. Mäkinen, Caj Haglund, Fabricio Passador-Santos, Tuula Salo, Ilmo Leivo, Harri Keski-Säntti, Valtteri Häyry, Camilla Böckelman, Timo Sorsa |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Tongue squamous cell carcinoma Matrix metalloproteinase Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Tongue medicine 030304 developmental biology 0303 health sciences Tumor size business.industry Cancer medicine.disease 3. Good health medicine.anatomical_structure Otorhinolaryngology Cervical lymph nodes 030220 oncology & carcinogenesis Periodontics Immunohistochemistry Biomarker (medicine) Oral Surgery business |
| Zdroj: | Journal of Oral Pathology & Medicine. 41:394-399 |
| ISSN: | 0904-2512 |
| DOI: | 10.1111/j.1600-0714.2011.01110.x |
| Popis: | J Oral Pathol Med (2012) 41: 394–399 Background: Oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and disease monitoring. Methods: Seventy-three consecutive T1N0M0 and T2N0M0 OTSCC patients treated at Helsinki University Central Hospital, Helsinki, Finland, in 1992–2002 were included. Tissue array blocks were prepared from primary tumors and immunostained. Immunoexpression of matrix metalloproteinase (MMP)-2, -8, -9, and -13 was compared with patient characteristics and outcome. Results: Nuclear expression of MMP-13, but not cytoplasmic expression of MMP-2, -8, and -9, was associated with invasion depth (P = 0.017) and tumor size (P = 0.008). Furthermore, high nuclear MMP-13 expression was predictive of poor outcome (P = 0.042). Conclusion: Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC. |
| Databáze: | OpenAIRE |
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