Computer Modeling of the Immune System Reconstruction after Peripheral Blood Stem Cell Transplantation

Autor:	Antoaneta Michova, Margarita Guenova, Gergana Bencheva, Lidia Gartcheva
Rok vydání:	2012
Předmět:	Transplantation Immune system medicine.anatomical_structure Leukopoiesis Ordinary differential equation White blood cell Peripheral Blood Stem Cell Transplantation medicine Delay differential equation Biology Stem cell Biological system Biomedical engineering
Zdroj:	Mathematical Modeling and Computational Science ISBN: 9783642282119 MMCP
DOI:	10.1007/978-3-642-28212-6_22
Popis:	A mathematical model for leukopoiesis has been proposed in literature, consisting of a system of ordinary differential equations with two delays. The aim of this study was to verify the assumption that the model is applicable also for T, B and NK cell recovery after stem cell transplantation and to tune the model parameters on the base of clinical data. The numerical tests illustrate the influence of the model parameters to the behavior of the monitored white blood cell populations. They also show that for certain parameter values the numerically obtained behaviour of B cells is in agreement with the clinical data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::32231628a5ee095821008e58a9d90807 https://doi.org/10.1007/978-3-642-28212-6_22 Zobrazit plný text záznamu