Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine

Autor:	Anton Ficai, Octavian Croitoru, Ionela Andreea Neacsu, Adina Turcu Stiolica, Costel Valentin Manda, Oana Ionescu, Johny Neamtu, Maria Viorica Ciocilteu, Emilia Amzoiu
Rok vydání:	2019
Předmět:	PLGA chemistry.chemical_compound Polymers and Plastics Mechanics of Materials Chemistry Materials Chemistry medicine Gentamicin General Chemistry Pharmacology medicine.drug
Zdroj:	Materiale Plastice. 56:534-527
ISSN:	2668-8220 0025-5289
DOI:	10.37358/mp.19.3.5224
Popis:	The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers (collagen) and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer. Regardless of the chosen method, the percentage of the encapsulated drug was found to be quite high: 15.92% in the Coll-HA-Genta material and 19.59% respectively in the PLGA-Genta biocomposite. The therapeutic value of gentamicin was improved by encapsulating it in delivery systems, contributing to sustained release for a long time (about 30 days).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::32204c723dfba5148dd35141d1f123d3 https://doi.org/10.37358/mp.19.3.5224 Zobrazit plný text záznamu