Basic fibroblast growth factor shows prognostic impact on survival in operable non-small cell lung cancer patients
Autor: | Guang-kuo Gao, Guang-li Shi, Baolan Li, Mingming Hu, Yi Han, Ying Hu |
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Rok vydání: | 2014 |
Předmět: |
Pulmonary and Respiratory Medicine
Oncology medicine.medical_specialty Pathology business.industry Angiogenesis Basic fibroblast growth factor Hazard ratio General Medicine medicine.disease Metastasis Vascular endothelial growth factor chemistry.chemical_compound chemistry Internal medicine medicine Endostatin business Lung cancer Survival analysis |
Zdroj: | Thoracic Cancer. 6:450-457 |
ISSN: | 1759-7706 |
DOI: | 10.1111/1759-7714.12202 |
Popis: | Background The important role of angiogenesis displaying in tumor development and metastasis has been generally realized. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endostatin (ES) are critical members of angiogenesis modulating the balance between pro-angiogenenic and anti-angiogenenic factors. The aim of this study was to evaluate the circulating level of these factors in serum and explore their prognostic significance in 96 operable non-small cell lung cancer (NSCLC) patients. Methods Pre-operational serum VEGF, bFGF, and ES were determined by commercially available enzyme-link immunosorbent assay for 96 NSCLC patients and compared to a cohort of healthy controls (n = 51). Values were correlated with clinicopathological features and overall survival (OS). Results The pretreatment serum levels of VEGF, bFGF and ES in NSCLC were significantly higher than in the healthy control (P < 0.001, P = 0.009 and P = 0.016, respectively). Univariate survival analysis showed that a high bFGF level correlated with shorter OS and remained an independent factor in multivariate analysis (hazard ratio [HR] = 1.918, 95% confidence interval [CI], 1.061–3.464). In the squamous subtype, a high bFGF indicated a particularly poor prognosis (HR = 2.609, 95% CI, 1.188–5.729). Conclusions bFGF is an independent predictor of poor survival in patients with NSCLC. For patients with high serum bFGF, aggressive antitumor treatments should be given after surgery. Approaches targeting the bFGF signaling pathway should be considered as potentially promising therapeutic strategies in NSCLC, especially for the squamous subtype. |
Databáze: | OpenAIRE |
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