Diagnostic Accuracy of Imaging for Liver Cirrhosis Compared to Histologically Proven Liver Cirrhosis
| Autor: | Kazuhide Shimamatsu, Toshinao Itani, Norio Usuki, Masamichi Kojiro, Masayuki Kanematsu, Masayoshi Kage, Yukio Osaki, Masatoshi Kudo, Soo Ryang Kim, Rong Qin Zheng, Yoshihiro Okabe, Hiroshi Kasugai, Katsuyoshi Ito, Hiroko Iijima |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Hepatitis
medicine.medical_specialty Cirrhosis genetic structures medicine.diagnostic_test business.industry Diagnostic accuracy Magnetic resonance imaging Retrospective cohort study medicine.disease Infectious Diseases Virology Carcinoma medicine Medical imaging Radiology Medical diagnosis business |
| Zdroj: | Intervirology. 51:17-26 |
| ISSN: | 1423-0100 0300-5526 |
| Popis: | Objective: To evaluate the diagnostic accuracy of liver cirrhosis by imaging modalities, including CT, MRI and US, compared to results obtained from histopathological diagnoses of resected specimens. Materials and Methods: CT, MRI and US examinations of 142 patients with chronic liver disease who underwent surgery for complicated hepatocellular carcinoma (Results: The differences in the five imaging parameters evaluated by CT, MRI and US between LC and CH were statistically significant (p < 0.001) except for the manifestations of portal hypertension on US. Irregular or nodular surface, blunt edge or morphological changes in the liver were selected as the best predictive signs for cirrhosis on US whereas liver parenchymal abnormalities, manifestations of portal hypertension and morphological changes in the liver were the best predictive signs on MRI and CT by multivariate analysis. The predictive diagnostic accuracy, sensitivity and specificity in discriminating LC from CH based on the best predictive signs were 71.9, 77.1 and 67.6% by CT; 67.9, 67.5 and 68.3% by MRI, and 66.0, 38.4 (lower than CT and MRI, p =0.001) and 88.8% (higher than CT and MRI, p =0.001)by US. According to the imaging impression scoring system, diagnostic accuracy, sensitivity and specificity were 67.0, 84.3 and 52.9% by CT; 70.3, 86.7 and 53.9% by MRI, and 64.0, 52.4 (lower than CT and MRI, p =0.0001) and 73.5% (higher than CT and MRI, p < 0.003) by US. ROC analysis showed that MRI and CT were slightly superior to US in the diagnosis of LC but no statistically significant difference was found between them. For the pathological diagnosis of P-LC, cirrhosis was diagnosed in 59.5, 46.7 and 41.7% of the P-LC cases by US, CT and MRI, respectively, with no significant difference among these methods. Conclusion: US, CT and MRI had different independent predictive signs for the diagnosis of LC. MRI and CT were slightly superior to US in predicting cirrhosis, especially regarding sensitivity. Noninvasive imaging techniques play an important role in the diagnosis of cirrhosis, especially in the evaluation of P-LC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|