ANAL CANAL SQUAMOUS CELL CARCINOMA TREATED WTH INTENSITY MODULATED RADIATION THERAPY BASED CONCURRENT CHEMORADIATION–RETROSPECTIVE ANALYSIS OF CLINICAL OUTCOME AND TOXICITIES
| Autor: | Lijeesh A L Dr, Jagathnath Krishna Dr, Roshni S Dr, C D Sivanandan Dr, Arun Sanker S Dr, Geethi M H Dr, Sajeed A Dr |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Anal canal squamous cell carcinoma
03 medical and health sciences medicine.medical_specialty 0302 clinical medicine business.industry 030220 oncology & carcinogenesis Retrospective analysis Medicine Concurrent chemoradiation Radiology Intensity-modulated radiation therapy business 030218 nuclear medicine & medical imaging |
| Zdroj: | INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :42-48 |
| DOI: | 10.36106/ijsr/7221426 |
| Popis: | Purpose: This retrospective analysis is aimed to report the single institution experience from an Asian country utilizing Intensity Modulated Radiotherapy (IMRT) based Chemo radiation in Anal Canal Squamous Cell Carcinoma (ASCC) with an emphasis on efcacy, toxicity and disease and treatment-related variables associated with outcomes. Study was conduc Materials And Methods: ted in the department of Radiation Oncology at Regional Cancer Center, Thiruvananthapuram. All Patients with biopsy proven ASCC diagnosed between January 2014 and December 2018 and receiving curative intent IMRT were identied and follow up data till December 2020 was collected. Primary end point was Disease-free survival (DFS). Secondary end points were Overall Survival (OS), Colostomy-free survival (CFS) Loco regional Failure (LRF) and Toxicities. A total of 34 patients were analyzed during a median follow up of Results: 34 months. Twenty ve patients (73.5%) were in stage IIIB. Median overall treatment time was 36 days. The estimated two year DFS, OS and CFS were 79.4 %, 93.9 %and 97% respectively. Disease recurrence at any point on follow up occurred in ve patients (14.7%). Primary Tumor size of more than or equal to 5 cm and development of grade three anemia during RT was associated with inferior DFS in Univariate analysis. Patients taken less than two cycles of chemotherapy, there was a trend for inferior OS. Acute grade 3 or more dermatological toxicities was 44% and hematological toxicity was 35.3%. Radiotherapy break occurred in 38.2%of patients with a median of 5.5 days (range 2-13). Of the available patients chronic toxicities were reported for 40% and were of grade 2. IMRT is associated with favorable toxicity rates and excellent Conclusion: long-term efcacy in Asian population also where patients are presenting in an advanced stage. Reducing the total treatment time by SIB technique may improve the clinical outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|