Clinical Trial of Vitamin D2vs D3Supplementation in Critically Ill Pediatric Burn Patients
| Autor: | Richard J. Kagan, Michele M. Gottschlich, Theresa Mayes, Jane C. Khoury |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vitamin
Burn injury medicine.medical_specialty Nutrition and Dietetics business.industry Medicine (miscellaneous) Parathyroid hormone 030208 emergency & critical care medicine 030209 endocrinology & metabolism Placebo Surgery Clinical trial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Internal medicine Vitamin D and neurology medicine Multivitamin business Total body surface area |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 41:412-421 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/0148607115587948 |
| Popis: | Background: Hypovitaminosis D exists postburn. However, evidence-based guidelines for vitamin D repletion are unknown. This investigation examined differences between D2 and D3 supplementation on outcome in children with burn injuries. Methods: Fifty patients with total body surface area burn of 55.7% ± 2.6% and full-thickness injury of 40.8% ± 3.8% were enrolled, ranging in age from 0.7–18.4 years. All participants received multivitamin supplementation per standardized clinical protocol. In addition, 100 IU/kg D2, D3, or placebo was administered daily during hospitalization using a randomized, double-blinded study design. Assay of total 25-hydroxyvitamin D (D25), 1,25-dihydroxyvitamin D (D1,25), 25-hydroxyvitamin D2 (25-OH-D2), 25-hydroxyvitamin D3 (25-OH-D3), and parathyroid hormone (PTH) was performed at 4 preplanned time intervals (baseline, midpoint, discharge, and 1 year postburn). Differences in vitamin D status were compared over time and at each specific study interval. Results: There were no sig... |
| Databáze: | OpenAIRE |
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