Blood eosinophils, exacerbations in the previous year, lung function and ICS dose predict frequent exacerbations in asthma
| Autor: | Andrei Malinovschi, Laurence Seidel, Florence Schleich, Renaud Louis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
biology Exacerbation business.industry medicine.disease Immunoglobulin E Logistic regression 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine 030228 respiratory system Internal medicine medicine biology.protein Blood eosinophils 030212 general & internal medicine Intensive care medicine business Prospective cohort study Lung function Asthma |
| Zdroj: | 5.2 Monitoring Airway Disease. |
| Popis: | The aim was to identify easily available predictors for future asthma exacerbations. Methods This is a prospective study on 250 asthmatics. Exacerbations in the following year was assessed by telephone interview. Logistic regression was used to test the relationship between the binary outcomes ( 1 % pred, FEV 1 /FVC, blood eosinophils (B-Eos), fibrinogen, CRP, IgE, gender, BMI, gastro-esophageal reflux, chronic rhinosinusitis, smoking and exacerbations in the last year. Results Asthmatic characteristics were described earlier (Schleich ERJ 2014). Sp-Eos and B-Eos were able to identify patients with ≥1 exacerbation with the same discriminative power. Taken together the prediction was not improved. The multiple regression identified that exacerbation in the previous year (OR=9.3), high doses ICS (OR=27.1), B-Eos (/mm³, OR=1.8) and FEV 1 /FVC (OR=0.93) were independent predictors of exacerbations in the following year (AUC:0.93). Frequent exacerbations (≥2) were predicted by exacerbations in the previous year (OR=10.5), high doses ICS (OR=39.2) and B-Eos (OR=3.5) (AUC:0.95). Conclusion B-Eos and Sp-Eos had similar predictive value for future exacerbations. This prediction was improved by combining lung function, ICS dose and history of exacerbations. |
| Databáze: | OpenAIRE |
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