Indolent CD8 + primary cutaneous T‐cell lymphoma involving the eyelid of an adolescent

Autor:	Kirby Taylor, Chad D. Housewright, Sophia J Hendrick, Andrew Siref, Lindsay M Bicknell, Jonathan H. Tsai, Andrew N. Minzenmayer
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Histology Proliferative index CD68 business.industry Not Otherwise Specified Dermatology medicine.disease Cutaneous lymphoma Pathology and Forensic Medicine Lymphoma medicine.anatomical_structure medicine Eyelid Differential diagnosis business CD8
Zdroj:	Journal of Cutaneous Pathology. 48:1489-1492
ISSN:	1600-0560 0303-6987
DOI:	10.1111/cup.14095
Popis:	Primary cutaneous acral CD8+ T-cell lymphoma (PCACTL) is currently a provisional entity defined as a rare cutaneous proliferation of atypical CD8+ lymphocytes that preferentially involves acral sites and has a good prognosis. We present a case of primary cutaneous CD8+ T-cell lymphoma involving the eyelid of an adolescent male. The case shares features with PCACTL, including indolent clinical behavior and expression of CD68 in a Golgi-associated dot-like pattern; however, other features differ significantly from PCACTL as currently defined by the World Health Organization (WHO). These features include ulceration, expression of CD56, granzyme B, and perforin, and a high proliferative index. Given these discrepancies, our case is currently best classified as a CD8+ primary cutaneous peripheral T-cell lymphoma, not otherwise specified. We review the differential diagnosis for this case and suggest expanding the definition of PCACTL. This article is protected by copyright. All rights reserved.
Databáze:	OpenAIRE
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