Reactions of polyfluorocarbonyl compounds with 1,3,3-trimethyl-3,4-dihydroisoquinoline and its derivatives

Autor:	B. B. Aleksandrov, N. D. Chkanikov, V. D. Sviridov, Yu. V. Shklyaev, M. S. Gavrilov, M. V. Galakhov, V. S. Shklyaev
Rok vydání:	1990
Předmět:	chemistry.chemical_compound Hexafluoroacetone chemistry Group (periodic table) Imine Organic chemistry General Chemistry Enamine
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 39:1268-1272
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00962396
Popis:	1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C- hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C1 CH3 group at 20°C. The products with the ketoesters are converted upon heating to γ-lactams. Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C1 CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20°C to give exclusively γ-lactams and do not give reaction products with hexafluoroacetone.
Databáze:	OpenAIRE
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