Acid catalyzed nitrile thiolysis of 3-amino-acrylonitriles, toward the synthesis of 3,4-substituted-5-amino-isothiazoles

Autor:	Ryan Thomas Backer, Alain Merschaert, Matthew J. Fisher, Kuklish Steven Lee, Aaron M. Kempema, Scott C. Mauldin
Rok vydání:	2015
Předmět:	Isothiazole chemistry.chemical_compound chemistry Nitrile Thiolysis Reagent Acid catalyzed Organic Chemistry Drug Discovery Organic chemistry Biochemistry
Zdroj:	Tetrahedron Letters. 56:2605-2607
ISSN:	0040-4039
Popis:	Application of an acid-catalyzed thioamidation of β-amino-acrylonitriles to the corresponding β-amino-thioacrylamides toward the synthesis of 3,4-substituted-5-amino-isothiazoles is described. The greatest yields were observed for examples with electron rich aromatic systems. This method uses inexpensive and easily handled reagents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31ecbbe4ee609422e239235cb6eb581e https://doi.org/10.1016/j.tetlet.2015.04.019 Zobrazit plný text záznamu Full Text from ScienceDirect