DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
| Autor: | Christopher G. England, Hao Yan, Zhilei Ge, Dawei Jiang, Christopher J. Kutyreff, Yan Liu, Steve Y. Cho, Peng Huang, Chunhai Fan, Junjun Hou, Hyung Jun Im, Jiye Shi, Dalong Ni, Weibo Cai, Jonathan W. Engle, Luhao Zhang, Yongjun Yan |
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| Rok vydání: | 2018 |
| Předmět: |
Biodistribution
Pathology medicine.medical_specialty medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Renal function Bioengineering 02 engineering and technology urologic and male genital diseases 010402 general chemistry 01 natural sciences Nephrotoxicity medicine DNA origami Kidney transplantation Dialysis Kidney urogenital system business.industry Acute kidney injury 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Computer Science Applications medicine.anatomical_structure 0210 nano-technology business Biotechnology |
| Zdroj: | Nature Biomedical Engineering. 2:865-877 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-018-0317-8 |
| Popis: | Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the antioxidant N-acetylcysteine—a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents. We evaluated the biodistribution of DONs non-invasively via positron emission tomography, and the efficacy of rectangular DONs in the treatment of AKI via dynamic positron emission tomography imaging with 68Ga-EDTA, blood tests and kidney tissue staining. DNA-based nanostructures could become a source of therapeutic agents for the treatment of AKI and other renal diseases. DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury. |
| Databáze: | OpenAIRE |
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