Transgenic Mouse Models Resistant to Diet-Induced Metabolic Disease: Is Energy Balance the Key?: Fig. 1

Autor:	Laura A. A. Gilliam, P. Darrell Neufer
Rok vydání:	2012
Předmět:	Pharmacology Genetically modified mouse medicine.medical_specialty Energy balance Energy metabolism Type 2 diabetes Biology medicine.disease Bioinformatics Obesity Pharmacotherapy Endocrinology Internal medicine medicine Molecular Medicine Gene Glycemic
Zdroj:	Journal of Pharmacology and Experimental Therapeutics. 342:631-636
ISSN:	1521-0103 0022-3565
DOI:	10.1124/jpet.112.192146
Popis:	The prevalence and economic burden of obesity and type 2 diabetes is a driving force for the discovery of molecular targets to improve insulin sensitivity and glycemic control. Here, we review several transgenic mouse models that identify promising targets, ranging from proteins involved in the insulin signaling pathway, alterations of genes affecting energy metabolism, and transcriptional metabolic regulators. Despite the diverse endpoints in each model, a common thread that emerges is the necessity for maintenance of energy balance, suggesting pharmacotherapy must target the development of drugs that decrease energy intake, accelerate energy expenditure in a well controlled manner, or augment natural compensatory responses to positive energy balance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31e84b161a95cb512834b535a13b58c7 https://doi.org/10.1124/jpet.112.192146 Zobrazit plný text záznamu