Abstract 028: Microbiota Composition And Diversity Is Associated With Trunk Fat: Findings From Baltimore Longitudinal Study Of Aging
| Autor: | Curtis Tilves, Toshiko Tanaka, Moira K Differding, Adam P Spira, Luigi Ferrucci, Noel T Mueller |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Circulation. 145 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background: Gut microbes have been associated with overall obesity in humans, including in monozygotic twins discordant on obesity, and they are sufficient to cause weight gain in mice. Trunk fat mass (TFM) is a stronger predictor of cardiometabolic diseases than overall obesity, but there is a dearth of human studies that have examined the association between gut microbiota and TFM using high-resolution shotgun metagenomic. Objective: To examine the association of gut microbiota diversity and composition with TFM. Methods: Baltimore Longitudinal Study of Aging is a racially diverse longitudinal cohort of adults ages ≥20. From 2013 to 2017, a subset of N=829 participants with DEXA scans for body composition also provided fecal samples for shotgun sequencing. We examined associations of microbiota alpha and beta diversity with TFM using ANCOVA and PERMANOVA, respectively. We tested for differential abundance of bacterial species across quartiles of TFM using ANCOM-BC. We then examined species significantly associated with TFM using splines and linear regression. All statistical models were adjusted for age, sex, and race. Results: Our analytic sample had a mean age of 70.5 years and BMI of 27.4 kg/m 2 , was 55.4% female, and 65.9% identified as White. TFM was associated with beta diversity (Weighted UniFrac pBacteroidetes : Firmicutes ( B / F ) ratio—a metric associated with obesity in prior studies—was associated with -0.55 kg (95%CI: -0.78, -0.31) lower TFM. After FDR-correction, four bacterial species ( R. gnavus, Clostridium, Blautia, Dorea spp. ) were associated with higher TFM, and in a monotonic fashion ( Figure ). These four species, but not the B / F ratio, remained significant after adjustment for BMI. Conclusion: In a large multiracial sample of US adults, four bacterial species were uniquely associated with abdominal fat independent of BMI. Future directions include verifying these associations in longitudinal models adjusting for lifestyle factors. |
| Databáze: | OpenAIRE |
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