Squamous cell carcinoma complicating chronic venous leg ulceration: a study of the histopathology, course and survival in 25 patients

Autor:	B T Baldursson, H Beitner, M A Hedblad, Bernt Lindelöf
Rok vydání:	1999
Předmět:	medicine.medical_specialty business.industry Cancer Retrospective cohort study Dermatology medicine.disease Gastroenterology Cancer registry Surgery Epidermoid carcinoma Internal medicine medicine Carcinoma Histopathology Skin cancer business Survival rate
Zdroj:	British Journal of Dermatology. 140:1148-1152
ISSN:	0007-0963
DOI:	10.1046/j.1365-2133.1999.02879.x
Popis:	We have studied 25 cases of squamous cell carcinoma in chronic venous leg ulcers. Twenty-three of the patients were dead and two were alive. The mean age at cancer diagnosis was 78.5 years. The median survival was 1 year. Eleven tumours were well-differentiated, 10 moderately and four poorly. All patients with a poorly differentiated tumour died within a year. Metastases were certain in eight cases. The disease was lethal in 10 cases which included all poorly differentiated tumours. The survival of the study group was significantly shortened compared with a control group of patients with lower limb non-melanoma skin cancer (n = 433) from the Swedish Cancer Registry (P = 0.0084). When diagnosed, squamous cell carcinoma in chronic leg ulcers merits a thorough investigation of the degree of differentiation and spread. Assertive treatment is indicated as poorly differentiated tumours and some moderately differentiated tumours may be fatal.
Databáze:	OpenAIRE
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