Titanium Dioxide Nanoparticles Induced Cytotoxicity in Rat Retinal Ganglion Cells under Ultraviolet B Irradiation
| Autor: | Hong Sheng Bi, Qiu Xin Wu, Dao Guang Wang, Da Dong Guo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Materials science Mechanical Engineering Radical medicine.disease_cause Photochemistry Retinal ganglion chemistry.chemical_compound chemistry Mechanics of Materials medicine General Materials Science Hydroxyl radical MTT assay Irradiation Cytotoxicity Genotoxicity |
| Zdroj: | Key Engineering Materials. :500-503 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.531-532.500 |
| Popis: | Titanium dioxide (TiO2) nanoparticles have been widely used in many fields, including biomedicine, cosmetics and environmental engineering. Recently, it was reported that TiO2 nanoparticles could exert genotoxicity on organisms via the generation of reactive oxygen species (ROS). In the present study, we investigated the effect of TiO2 nanoparticles on RGC-5 cells with or without ultraviolet (UV) B irradiation through MTT assay and determination of hydroxyl radical production. The results demonstrated that TiO2 nanoparticles could efficiently inhibit the growth of RGC-5 cells in the presence of UVB irradiation, whereas there was little impact on target cells in the absence of UV irradiation; UV irradiation could apparently increase the level of hydroxyl radicals in RGC-5 cells and further efficiently inhibit the growth of RGC-5 cells, suggesting that UV irradiation plays an important role in growth inhibition in RGC-5 cells exposed to TiO2 nanoparticles. |
| Databáze: | OpenAIRE |
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