Oral Azithromycin Pulse Therapy and Daily Topical Adapalene in the Treatment of Acne Vulgaris: An Open Randomized Noncomparative Study

Autor:	Akramullah Sikder, Mohammad Jamal Uddin, Mohammod Abu Hena Chowdhury, M Mujibul Hoque, Rashed Md. Khan, Shameem Al Mamun
Rok vydání:	2017
Předmět:	Papular Lesion medicine.medical_specialty business.industry Pulse therapy Azithromycin medicine.disease Dermatology Lesion Adapalene Concomitant medicine medicine.symptom Adverse effect business Acne medicine.drug
Zdroj:	Medicine Today. 28:52-56
ISSN:	2408-8714 1810-1828
DOI:	10.3329/medtoday.v28i2.32925
Popis:	The safety and efficacy of oral azithromycin and topical adapalene are well documented. In this study, concomitant use of oral azithromycin pulse therapy and daily topical adapalene in the treatment of acne vulgaris is assessed. A total of 37 patients fulfilled the inclusion criteria were enrolled. Azithromycin, 500 mg orally once daily first 3 days of 10 days' cycle for 9 cycle & topical Adapalene (0.5%) at night. Patients evaluated at 4 weeks' interval by using Michaelsson acne severity index. The overall assessment was made by percent reduction of acne lesions and severity score. At the end of 12 weeks' treatment 99.8% of comedones, 98.7% papular lesion, 94.3% pustular lesion and 88.8% infiltrated lesion were cleared. Only 2.9% cystic lesion responded to the regimens. Percent reduction of Michaelsson acne severity index was 87%, which was statistically highly significant. Overall assessment revealed acne lesion cleared in 22% cases, excellent improvement observed in 65% and 13% showed good response. Adverse effect was minimal. So, azithromycin pulse therapy and topical adapalene is indeed effective and safe in the treatment of acne vulgaris.Medicine Today 2016 Vol.28(2): 52-56
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31d6971f2600950bfeb7fe5f00a4cea4 https://doi.org/10.3329/medtoday.v28i2.32925 Zobrazit plný text záznamu