| Autor: |
Naglaa Khalifa, Ahmed Abdel Moniem, Yasser mustafa abdelazim abdel hamid, Usama El-Safy |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zagazig University Medical Journal. |
| ISSN: |
2357-0717 |
| DOI: |
10.21608/zumj.2020.31650.1867 |
| Popis: |
Background: Bacterial sepsis is a life threatening crisis with high mortality and morbidity in neonates, Reliable marker is needed for the diagnosis of neonatal sepsis so that early treatment can be initiated. C-reactive protein (CRP), IL-6 can be used as Reliable markers for the diagnosis of neonatal sepsis so that early treatment can be initiated.Aim of the work: to detect the levels of IL-6, CRP and HS-CRP in clinically suspected cases of neonatal sepsis and evaluation and analysis of these parameters as early markers of neonatal sepsis.Patients and methods: A prospective cohort study was conducted on 60 neonates at neonatal intensive care unit of pediatric department and clinical pathology department at Zagazig university hospitals.Results: IL-6 at a cut off value of 187.5Pg/ml had sensitivity of 87.5% and specificity of 63.6% with a negative predictive value of 93.3%. HS-CRP at a cut off value of 3.3 Mg/L had a higher sensitivity but a lower specificity at 100% and 47.7% repectively. CRP showed higher specificity than HS-CRP and IL-6 with 61.7% with a negative predictive value of 90%. A combination of IL-6 and CRP showed improvement of sensitivity to 100% and a negative predictive value of 100% and is more cost effective than the combination of IL-6 and HS-CRP which showed similar sensitivity and negative predictive value but showed less specificityConclusion: a combination of IL-6 and HS-CRP would be a sensitive test for early diagnosis of neonatal sepsis at a sensitivity of 100% and a similar NPV |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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