Role of mRNA Expression in the Nasal Polyp Pathogenesis

Autor:	Murat Salihoglu, Ersoy Tufan, Huseyin Baloglu, Atila Gungor, Ismail Yilmaz
Rok vydání:	2012
Předmět:	education.field_of_study Pathology medicine.medical_specialty business.industry Mrna expression Population stat Pathogenesis Otorhinolaryngology Complementary DNA Medicine Surgery GAPDH Gene Airway education business Gene
Zdroj:	Otolaryngology–Head and Neck Surgery. 147
ISSN:	1097-6817 0194-5998
DOI:	10.1177/0194599812451426a414
Popis:	Objective: Nasal polyposis (NP) not only has a significant impact on the life quality of patients but also affects 2.11% of the population is a chronic inflammatory disease of the upper airway. The aim of this study is to evaluate and understand nasal polyp pathogenesis.Method: Healthy mucosa and polyp samples were taken from 27 patients with nasal polyposis who underwent FESS. Total RNA was extracted from samples and converted to cDNA. Expressions of five given genes namely CC10, DMBT1, LTF, STAT, PIP were detected using QRT-PCR technique. GAPDH gene were used for normalization.Results: While there was no significant change in CC10 expression levels, we observed significant increase in the expressions of DMBT1, LTF, STAT and PIP compared to polyp tissue with healty mucosa.Conclusion: We observed significant changes in the expressions of DMBT1, LTF, STAT and PIP genes which are kniwn with anti-inflammatory, antimicrobial, immunomodulatory, and antineoplastic properties.
Databáze:	OpenAIRE
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