Genome Diversity and Dynamics in Candida albicans
| Autor: | Marie-Elisabeth Bougnoux, Emilie Sitterlé, Natacha Sertour, Adeline Feri, Jeanne Ropars, Mélanie Legrand, Corinne Maufrais, Raphaël Loll-Krippleber, Christophe d'Enfert, Timea Marton |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics education.field_of_study Genetic diversity biology 030106 microbiology Population respiratory system biology.organism_classification Phenotype Genome Corpus albicans Parasexual cycle 03 medical and health sciences 030104 developmental biology Genetic structure Candida albicans education human activities |
| Zdroj: | Candida albicans: Cellular and Molecular Biology ISBN: 9783319504087 |
| DOI: | 10.1007/978-3-319-50409-4_11 |
| Popis: | The fungal pathogen Candida albicans shows significant diversity at the genetic and phenotypic levels. In this Chapter, we review our current knowledge of the C. albicans diploid genome and its variability, the genetic structure of the C. albicans population and the mechanisms that are involved in C. albicans genome dynamics, with a focus on the parasexual cycle and loss-of-heterozygosity events. We further explore the impact of genetic diversity and genome dynamics on C. albicans phenotypic diversity. Finally, we discuss how our current knowledge of C. albicans genetic diversity could be leveraged in the future in order to get insights in the mechanisms underlying important biological attributes that are subject to variations across C. albicans isolates. |
| Databáze: | OpenAIRE |
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